io.github.cyanheads/chembl-mcp-server

up checked 2026-11-11T12:37:41.565Z

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Publisher-provided description

Link compounds to protein targets, rank bioactivity, and look up drug mechanisms and indications.

Summary by lookupd

Queries ChEMBL for compound-target bioactivity, drug mechanisms and indications, assay details, and target lookups, with SQL ranking over…

Install

Claude Code, remote (streamable-http)

claude mcp add --transport http chembl-mcp-server https://chembl.caseyjhand.com/mcp

Claude Code, npm package (stdio)

claude mcp add chembl-mcp-server -- npx -y @cyanheads/chembl-mcp-server

Claude Code, npm package (stdio)

claude mcp add chembl-mcp-server -- npx -y @cyanheads/chembl-mcp-server

Codex, remote (streamable-http)

codex mcp add chembl-mcp-server --url https://chembl.caseyjhand.com/mcp

Codex, npm package (stdio)

codex mcp add chembl-mcp-server -- npx -y @cyanheads/chembl-mcp-server

Codex, npm package (stdio)

codex mcp add chembl-mcp-server -- npx -y @cyanheads/chembl-mcp-server

Cursor, remote (streamable-http) → .cursor/mcp.json

{
  "mcpServers": {
    "chembl-mcp-server": {
      "url": "https://chembl.caseyjhand.com/mcp"
    }
  }
}

Cursor, npm package (stdio) → .cursor/mcp.json

{
  "mcpServers": {
    "chembl-mcp-server": {
      "command": "npx",
      "args": [
        "-y",
        "@cyanheads/chembl-mcp-server"
      ]
    }
  }
}

Cursor, npm package (stdio) → .cursor/mcp.json

{
  "mcpServers": {
    "chembl-mcp-server": {
      "command": "npx",
      "args": [
        "-y",
        "@cyanheads/chembl-mcp-server"
      ]
    }
  }
}

Other clients: docs. Or tell your agent: Set up lookupd for me: read https://lookupd.com/agent.md and follow it.

Tools (7 tools)

Publisher-provided text

• chembl_search_molecules Discovery entry point for compounds. Find by name / ChEMBL ID / InChIKey with the default search_type=name (supply query), or run a structure search with search
• chembl_get_bioactivities The flagship compound↔target bioactivity bridge: measurements for a molecule (target deconvolution / selectivity), a target (lead finding), or both together (ho
• chembl_search_targets Resolve a protein/gene/UniProt accession to the ChEMBL target ID that chembl_get_bioactivities needs for the target→leads workflow. Supply at least one of acces
• chembl_get_drug_info Pharmacology for a drug (molecule): mechanism(s) of action, the molecular target(s) it acts on, action type (inhibitor / agonist / …), first-approval year, and
• chembl_get_assay Assay provenance behind a bioactivity row: description, type (binding / functional / ADMET / toxicity), the target it measures, organism, and ChEMBL's 1–9 confi
• chembl_dataframe_query Run a read-only SQL SELECT over the bioactivity rows chembl_get_bioactivities staged on a canvas — rank, group, dedupe, and aggregate across the FULL set, not t
• chembl_dataframe_describe List the tables and columns staged on a canvas by chembl_get_bioactivities — inspect before calling chembl_dataframe_query to write correct SQL. Returns each ta

Changes

Newest first, as lookupd saw them

• 2026-11-11: version 0.5.0 → 0.6.0

Details

• Version: 0.6.0
• Transports: streamable-http, stdio
• Uptime (7 days): 100%
• Median latency: 602 ms
• First indexed: 2026-11-01T09:25:52.261Z
• Last seen in registry: 2026-11-11T17:17:20.152Z
• Repository: https://github.com/cyanheads/chembl-mcp-server

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